National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Extended spectrum beta-lactamase –Klebsiella pneumoniae (ESBL -KP) is one of the leading causes of nosocomial infections seen with increasing prevalence worldwide. The present study was undertaken to know the prevalence of ESBL-KP and their antibiotic susceptibility pattern and to create a baseline antibiotic resistance data to implement effective infection control policy. A total of 225 non duplicate K. pneumoniae isolates were obtained from various clinical samples over a period of 18 months. Antibiotic susceptibility testing and ESBL detection was done by Kirby Bauer’s disc diffusion and CLSI methods respectively. Highest resistance of 91.5% was noted to amoxicillin-clavulanic acid. Least resistance was recorded to imipenem (24.4%) and amikacin (39.1%). Resistance of > 85% was noted to third generation cephalosporins [85.7% each to cefotaxime and ceftriaxone; ceftazidime (91%)].ESBL positivity was 46.6%. ICU, wards and outpatient isolates revealed ESBLs of 51.3%, 39.7% and 52.7% respectively. Multi-drug resistance was 60%.Antibiotic resistance was higher in ICU isolates. Imipenem and amikacin may be preferred antibiotics in treating K pneumoniae infections.
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