Enzymatic Synthesis of Memantine (Memary) Oligosaccharides (Gluco-oligosaccharides) and their application as anti-dementia drugs that cross the Blood-Brain Barrier (BBB)

Hiroki Hamada; Kohji Ishihara; Kei Shimoda; Atsuhito Kuboki; Yuya Kiriake<sup> </sup>; Ryusuke Hosoda

doi:https://doi.org/10.20546/ijcmas.2023.1208.001

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Original Research Articles Volume : 12, Issue:8, August, 2023

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Int.J.Curr.Microbiol.App.Sci.2023.12(8): 1-6

DOI: https://doi.org/10.20546/ijcmas.2023.1208.001

Enzymatic Synthesis of Memantine (Memary) Oligosaccharides (Gluco-oligosaccharides) and their application as anti-dementia drugs that cross the Blood-Brain Barrier (BBB)

Hiroki Hamada¹*, Kohji Ishihara², Kei Shimoda³, Atsuhito Kuboki²,Yuya Kiriake⁴and Ryusuke Hosoda⁵

¹Meisterbio Co. Ltd., 29-13Ekimoto-cho, Kita-ku, Okayama 700-0024, Japan
²Department of Biological Science, Faculty of Life Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan
³Department of Biomedical Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi,
Oita 879-5593, Japan
⁴Faculty of Medicine and Health Sciences, Yamaguchi University, 1-1-1 Minamikogushi,
Ube-shi, Yamaguchi 755-8505, Japan
⁵Department of Pharmacology, School of Medicine, Sapporo Medical University,
Sapporo 060-8556, Japan

^*Corresponding author

Abstract:

Memantine (memary) oligosaccharides (gluco-oligosaccharides) were synthesized by enzymatic glycosylation, using cyclodextrin glucanotransferase as a biocatalyst. Although memantine hardly crosses the blood–brain barrier (BBB) in the mouse brain, memantine oligosaccharides crossed the BBB of mouse brain and were incorporated into the mouse brain tissue. Our investigations indicated that memantine modified with oligosaccharides might have gained a BBB-crossing ability. Furthermore, during the Y-maze test using senescence-accelerated mouse prone 8, our study revealed that the time spent in the novel Y-maze arm by the memantine-oligosaccharides-treated mouse was longer than that spent in the novel arm by the memantine-treated-mouse. Therefore, this study established that since memantine oligosaccharides could penetrate the BBB of mouse brain and be incorporated into the mouse’s brain tissue, they could also enhance spatial learning.

Keywords: Memantine oligosaccharides, Blood-brain barrier, Spatial learning, Brain-drug-delivery

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Hiroki Hamada, Kohji Ishihara, Kei Shimoda, Atsuhito Kuboki, Yuya Kiriake and Ryusuke Hosoda. 2023. Enzymatic Synthesis of Memantine (Memary) Oligosaccharides (Gluco-oligosaccharides) and their Application as Anti-dementia Drugs that Cross the Blood-brain Barrier (BBB).Int.J.Curr.Microbiol.App.Sci. 12(8): 1-6. doi: https://doi.org/10.20546/ijcmas.2023.1208.001

Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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Original Research Articles Volume : 12, Issue:8, August, 2023

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