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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): 1232-1239
DOI: https://doi.org/10.20546/ijcmas.2017.604.151


Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Hospital, Nanded, Maharashtra, India
Sanjay Kumar R. More1*, Kasturi2, Vimal S. Rathod2, Rohit Sinha2 and Saleha Khan2
1Department of Microbiology, Swami Ramanand Teerth Rural Govt. Medical College, Ambajogai, Maharashtra, India
2Department of Microbiology, Dr. S C Govt. Medical College, Nanded, Maharashtra, India
*Corresponding author
Abstract:

Staphylococcus aureus is one of the most common organisms causing nosocomial and community acquired infections worldwide. Antibiotic resistance in this organism has become an ever-increasing problem. Present study was undertaken to determine the percentage of Staphylococcus aureus isolates having inducible clindamycin resistance. A total of 270 Staphylococcus aureus isolated from different specimens were subjected to routine antibiotic sensitivity testing by Kirby Bauer disc diffusion method. All isolates were tested for Methicillin resistance by using Cefoxitin 30 μg disc. Inducible clindamycin resistance was detected by ‘D’ test as per CLSI guidelines. Among the 270 S. aureus isolates, 124 (45.92%) were detected as MRSA, 116 S. aureus isolates (42.96 %) were resistant to Erythromycin and 41 (15.16 %) isolates were D-test positive. Both inducible and constitutive clindamycin resistance was higher among MRSA compared to MSSA. High prevalence of strains with inducible clindamycin resistance particularly among MRSA indicates that inducible clindamycin resistance testing (D-test) should be included as a part of routine antibiotic susceptibility. These isolates may be missed in routine antibiotic testing by disk diffusion method.


Keywords: Staphylococcus aureus, MRSA, D test, Inducible clindamycin resistance.
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How to cite this article:

Sanjay Kumar R. More, Kasturi, Vimal S. Rathod, Rohit Sinha, Saleha Khan. 2017. Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus in a Tertiary Care Hospital, Nanded, MaharashtraInt.J.Curr.Microbiol.App.Sci. 6(4): 1232-1239. doi: https://doi.org/10.20546/ijcmas.2017.604.151