National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Filgrastim (Colstim®) is a recombinant Methionyl Human Granulocyte Colony-Stimulating Factor (r-metHuG-CSF) analog used to stimulate the proliferation and differentiation of granulocytes in humans undergoing chemotherapy with granulocyte values below 0.5 G/l likely to be threatened by infections, including sepsis possibly with a fatal outcome. A four month old female Rottweiler pup was presented to the TVCC, RIVER with the history of vomiting and melena for the past two days. Further enquiry revealed that the pup had properly been immunized against all infectious diseases. Clinical examination showed a pink and moist conjunctival mucosa, rectal temperature of 38.7º C, hear rate 150 bpm, and capillary refill time of 3 seconds. The ECG showed a normal study. Laboratory examination revealed Hb - 15.6 g %, PCV - 45.5%, RBC count - 5.87 millions/mm3, WBC count - 1000 cells/ mm3, platelets - 4.21 lakhs/ mm3, MCV - 77.6 fl, MCH - 26.5 pg, MCHC - 34.2%. Absolute count of Neutrophils - 500 cells/ mm3, Lymphocytes - 450 cells/ mm3, Monocytes - 40 cells / mm3 and Eosinophils - 10 cells/ mm3. However, serum biochemistry showed normal values but with an increase in Creatine kinase of 567 U/L. The dog was treated with Filgrastim @ 10 µg/ kg b.wt. S.c along with other supportives. After 5 days of therapy the dog recovered uneventfully.
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