|PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
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Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38
Streptococcus pneumoniae is the most common cause of community-acquired respiratory tract infections and one of the common causes of morbidity and mortality in developing countries. Penicillin has been the drug of choice for treatment of pneumococcal infections but there is increasing number of reports of penicillin resistant pneumococci (PRP) reported throughout the world. There is also an increase in multidrug-resistant strains. However, there are very less reports available from India. Aims: The aim of the study is to isolate and identify Streptococccus pneumoniae in clinical samples and to screen for penicillin resistance and study the antibiotic resistance pattern. S. pneumoniae was identified with Gram staining, bile solubility, inulin fermentation and sensitivity to optochin as per standard technique. Penicillin resistance was screened by oxacillin (1µg) disk on Muller-Hinton blood agar followed by Minimum Inhibitory Concentration (MIC) detection by the E-strip method according to the Clinical Laboratory Standards Institute (CLSI) guidelines. Antibiotic susceptibility for other antibiotics was carried out by the Kirby Bauer disk diffusion method followed by an E-test method. Out of 10 isolates, 20% showed total resistance to penicillin, and 20% showed intermediate resistance. These penicillin-resistant pneumococci (20%) were also found to be multidrug-resistant (MDR) strains. Maximum resistance was observed for cotrimoxazole (60%), followed by tetracycline and cefotaxime (40%). Conclusions: Increasing emergence of the resistant strains of S. pneumoniae in the community set up requires continuous monitoring and a restricted use of antibiotics to keep a check on its resistance pattern, for an effective treatment plan.