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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Peste des petits ruminants (PPRV) is a highly contagious transboundary viral disease of small ruminants with widespread distribution and poorly characterized molecular pathogenesis. The present study aimed at delineating the role of NF-kB signalling pathway during PPRV infection in the in-vitro system. For this the gene expression of three major regulatory proteins of NF-kB pathway viz. IKBα, IKKβ and RelA were analysed in the PPRV infected and mock infected Vero cells as a function of time using SYBR-green based one-step RT-qPCR. The results genes revealed downregulation of IKBα gene and upregulation of RelA and IKKβ genes in the PPRV infected group as against mock infected during initial hours of infection.