National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Urinary tract infection (UTI) represents the most common bacterial infection in pregnancy. Urinary tract infection poses a serious health threat because of the antibiotic resistance and high recurrence rate. Extended Spectrum Beta-Lactamases (ESBLs) producing Enterobacteriaceae are among the most problematic multidrug resistant bacteria worldwide and are increasingly causing urinary tract infection both in hospitalized patients and outpatients making infections difficult to treat. This study was undertaken to identify the changing etiological trends of urinary tract infections (UTI), detect the prevalence of ESBL producing Uropathogens and study their antibiotic resistance profile. Urinary isolates from symptomatic UTI cases were identified by conventional methods. Antimicrobial susceptibility testing was done by Kirby Bauer’s disc diffusion method. Isolates resistant to cephotaxime were tested for ESBL production by double disc synergy test method. Total 6 ESBL producing organisms were isolated out of 54-gram negative bacilli among 170 urine samples of pregnant women. The most predominant ESBL producing isolates were Escherichia coli (37.5%), followed by Citrobacter frundii (25.0%) and Klebsiella pneumoniae (12.5%). The antibiogram pattern of ESBL producing isolates showed maximum sensitivity to Imipenem (75.0%), Meropenem (75.0%) and Gentamicin (62.5%). This study shows that the Prevalence rate of ESBL producing E. coli and Citrobacter freundii is high in pregnant women. Most of the ESBL producing isolates were multidrug resistant. Careful detection of ESBL production and antimicrobial susceptibility testing are necessary to avoid treatment failure in patients with UTI.
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