The objective of the present study is 1. To study the changing laboratory profiles in dengue viral infections. 2. To correlate these laboratory tests during the evolution of dengue fever and in assessing severity of disease. 3. To study the association of these profiles in remission of the disease. 4. And also to study factors involved in predicting prognosis. A total number of 110 cases which were dengue IgM Seropositive (by ELISA capture method) were included in the study from Department of Microbiology, Chalmeda Anand Rao Institute of Medical Sciences, over a period of 1 year from August 2015 to July 2016. These cases were analysed for blood counts, platelet counts, blood urea, Serum creatinine, serum aspartate aminotransferases and alanine aminotransferases concentration. Male to female sex ratio was 1.4:1, with majority of cases in age group of 10 to 20 years. Haematological parameters studied were, haemoglobin assay, majority of patients in CD had haemoglobin values ranging from 11.1to15gms, slight variations were seen in DHF, DSS. PCV studies showed no changes in CD patients, while, more than 20% increase from baseline values was noted in DHF (12 of 21 patients) and in DSS (3of 3 patients). Lymphocytosis with reactive forms was common finding in 70 members of 110 patients, reactive forms were more in leucopenia patients. Platelets counts showed decrease in 49 of 86 patients in CD, 8members of 21 in DHF, and 2 out of 3patients in DSS. Thrombocytopenia was marked in age group below 15years. CD and DHF had moderate thrombocytopenia, where as DSS showed marked decrease in counts. Serial follow up of platelet counts showed a dip in platelet values at day 4 to 5,followed by gradual recovery in 10 to 12days.In renal function tests, 67 members in CD had normal range and only 6 members showed elevated levels. DHF showed urea in range of 10 -15 mg/dl in 11 members out of 21, in DSS 2 patients had increased blood urea levels. Serum creatinine levels were slightly reduced in age group below 15years. Liver functions tests were also altered with increase in ALT and AST levels in severe cases. Dengue Ig M Seropositive in concordance with Peripheral blood studies are of great significance along with Haematocrit values in assessment of disease, and its progression to severe forms. Also, these parameters help in indicating the prognosis of patient and course of remission. 

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