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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
journals IJCMAS
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 234-239
DOI: http://dx.doi.org/10.20546/ijcmas.2016.512.025


Effects of Esteradiol and Testosterone on Tissue Antioxidant Status and Susceptibility to Subdiabetogenic Dose of Alloxan in Male Rats
Sadiq M.A. AL-Hiti*
College of Pharmacy, Department of Pharmacology and Toxicology, Baghdad University, Iraq
*Corresponding author
Abstract:

This study was designed to investigate the influence of estradiol and testosterone on the major tissues antioxidant, glutathione (GSH), and the lipid peroxidation product, malondialdehyde (MDA) in various tissues of gonadectomized rats. Also, the susceptibility of sex hormones pretreated rats to the subdiabetogenic dose of alloxan (Alx) were also studied. Castration was associated only with elevation of pancreatic GSH content compared to controls. Testosterone treatment normalized pancreatic GSH content, but decreased those of kidney and liver. Also it elevated MDA levels in almost all studied tissues. Interestingly, pretreatment of male rats with testosterone (but not estradiol) increased the susceptibility of rats to the subdiabetogenic dose of ALX, as manifested by glucosurea and mild hyperglycemia. Control rats failed to respond to ALX.


Keywords: Estradiol, Testosterone, Antioxidant, Glutathione, Malondialdehyde, Alloxan and antidiabetogenic.
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How to cite this article:

Sadiq M.A. AL-Hiti. 2016. Effects of Esteradiol and Testosterone on Tissue Antioxidant Status and Susceptibility to Subdiabetogenic Dose of Alloxan in Male Rats.Int.J.Curr.Microbiol.App.Sci. 5(12): 234-239. doi: http://dx.doi.org/10.20546/ijcmas.2016.512.025