|PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : email@example.com / firstname.lastname@example.org
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38
This study was designed to investigate the influence of estradiol and testosterone on the major tissues antioxidant, glutathione (GSH), and the lipid peroxidation product, malondialdehyde (MDA) in various tissues of gonadectomized rats. Also, the susceptibility of sex hormones pretreated rats to the subdiabetogenic dose of alloxan (Alx) were also studied. Castration was associated only with elevation of pancreatic GSH content compared to controls. Testosterone treatment normalized pancreatic GSH content, but decreased those of kidney and liver. Also it elevated MDA levels in almost all studied tissues. Interestingly, pretreatment of male rats with testosterone (but not estradiol) increased the susceptibility of rats to the subdiabetogenic dose of ALX, as manifested by glucosurea and mild hyperglycemia. Control rats failed to respond to ALX.