National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Non-fermenting gram-negative bacilli (NFGNB) are an emerging problem in Blood stream infections. A major concern is multi-drug resistance which severely limits treatment options. Earlier it was believed to be non pathogenic, but recently they are more frequently isolated as primary pathogen. Usually they cause hospital acquired infection (HAI). A prospective study was conducted to isolate the NFGNB from blood samples, to identify the risk factors leading to blood stream infections and to determine the antibiotic susceptibility pattern of them. The study was conducted in a tertiary care hospital, over a period of 2 years. Identification of NFGNB was done by biochemical tests and by VITEK 2. Antibiotic susceptibility was determined by disc diffusion method. Extended-spectrum β-lactamases (ESBLs) and metallo-β-lactamases (MBLs) production were detected by the combined disc diffusion test. Out of 2021 blood samples, blood culture positive was in 32.7% of patients of whom the cause was NFGNB. Acinetobacter boumannii was the most common organism, 27.69% followed by Strenotrophomonas maltophilia, next to it was Pseudomonas aeruginosa Acinetobacter lwoffiietc. The most common risk factors for colonization BSIs with NFGNB was comorbid conditions, such as diabetes mellitus, cardiovascular diseases, hypertension, tuberculosis and chronic renal disease patients on haemodialysis. In general, the isolates of NFGNB revealed pretty much good sensitivity to carbapenem (imipenem, ertepenam), colistin and aminoglycosides (amikacin, gentamicin), where as cephalosporin group revealed a low susceptibility rate. ESBL and MBL producer NFGNB were identified and the isolation rate is very alarming. The trend of increasing numbers of cases of NFGNB in Blood stream infections compounded by MDR is of great concern. It is necessary to administer antibiotics judiciously, strengthen surveillance and laboratory services in intensive care units, and re-evaluate treatment guidelines for management of infection by these organisms.
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