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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(11): 183-195
DOI: http://dx.doi.org/10.20546/ijcmas.2016.511.021


Association of the RETN–420C˃G Polymorphism with Rheumatoid Arthritis in an Egyptian Population
Marwa M.E. Abd-Elmonsef1*, Naglaa F. Ghoname1, Abeer Shahba2, Maha M. Hagras3, Lamees M. Dawood4 and Mohamed M.E. Abd-Elmonsef5
1Department of Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt
2Department of Internal Medicine, Faculty of Medicine, Tanta University, Egypt
3Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt
4Department of Biochemistry, Faculty of Medicine, Tanta University, Egypt
5Department of Mathematics, Faculty of Science, Tanta University, Egypt
*Corresponding author
Abstract:

To investigate the relation of the resistin gene promoter single nucleotide polymorphism (RETN–420C>G) with the serum resistin concentration and rheumatoid arthritis (RA) risk, and if there is any association with the disease activity and autoimmunity. This study included 128 patients with RA (64 active and 64 in remission) and 64 controls. Serum resistin was measured for all subjects by ELISA. Other markers of inflammation and disease activity were also assessed.  All subjects were genotyped for RETN–420C>G polymorphism using PCR-RFLP. Serum resistin was significantly higher in active RA patients compared to inactive patients and controls. Patients with CG and GG genotypes had increased risk of RA compared to CC carriers (OR = 1·88, P= 0.049, OR = 4.84, P = 0.046, respectively). Highly significant level of resistin was detected with variant genotypes. Highly significant association was found between the investigated polymorphism and the parameters of the disease activity, but not autoimmunity. This is the first study suggesting the relationship between RETN –420C>G polymorphism and both the risk of RA and its activity, but not autoimmunity. More studies of different populations and larger samples are required to confirm these observations.


Keywords: Rheumatoid arthritis,RETN gene, polymorphism, resistin.
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How to cite this article:

Marwa M.E. Abd-Elmonsef, Naglaa F. Ghoname, Abeer Shahba, Maha M. Hagras, Lamees M. Dawood and Mohamed M.E. Abd-Elmonsef. 2016. Association of the RETN –420C˃G Polymorphism with Rheumatoid Arthritis in an Egyptian PopulationInt.J.Curr.Microbiol.App.Sci. 5(11): 183-195. doi: http://dx.doi.org/10.20546/ijcmas.2016.511.021