ABSTRACT

This work is of used on the evaluation of the anti-inflammatory and antimicrobial activities of stem and leaf extracts of Pergularia daemia and Solanum xanthocarpum. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti inflammatory activity. The anti inflammatory activity of the ethanol extracts of stem and leaves were compared to that of the standard drug hydrocortisone. The percentage protection of lysis for Standard hydrocortisone 0.08 mg/ml is 97.9±0.24%, the maximum percentage protection of lysis was observed in ethanol extract of Pergularia daemia stem 12.0 mg/ml is 78.58±0.33%. In vitro antimicrobial activity of crude stem and leaf extracts of these 2 plants was tested by well diffusion method against 4 bacteria and 4 fungi. Among the two plant extracts tested, Solanum xanthocarpum showed more antibacterial activity against the organisms compared to Pergularia daemia.  Therefore these herbal extracts could be used in future direction as alternative therapeutic agents for the treatment of human diseases.

Keywords : Pergularia daemia; Solanum xanthocarpum;in vitro anti-inflammatory; HRBC